Ontology highlight
ABSTRACT:
SUBMITTER: Maachi H
PROVIDER: S-EPMC7034189 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Maachi Hasna H Fergusson Grace G Ethier Melanie M Brill Gabriel N GN Katz Liora S LS Honig Lee B LB Metukuri Mallikarjuna R MR Scott Donald K DK Ghislain Julien J Poitout Vincent V
Diabetes 20191227 3
The molecular mechanisms of β-cell compensation to metabolic stress are poorly understood. We previously observed that nutrient-induced β-cell proliferation in rats is dependent on epidermal growth factor receptor (EGFR) signaling. The aim of this study was to determine the role of the EGFR ligand heparin-binding EGF-like growth factor (HB-EGF) in the β-cell proliferative response to glucose, a β-cell mitogen and key regulator of β-cell mass in response to increased insulin demand. We show that ...[more]