Ontology highlight
ABSTRACT:
SUBMITTER: Leonard S
PROVIDER: S-EPMC4886680 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Leonard Siobhán S Kinsella Gemma K GK Benetti Elisa E Findlay John B C JBC
Scientific reports 20160531
Type 2 diabetes is a chronic metabolic disorder primarily caused by insulin resistance to which obesity is a major contributor. Expression levels of an orphan G protein-coupled receptor (GPCR), GPR21, demonstrated a trend towards a significant increase in the epididymal fat pads of wild type high fat high sugar (HFHS)-fed mice. To gain further insight into the potential role this novel target may play in the development of obesity-associated type 2 diabetes, the signalling capabilities of the re ...[more]