Ontology highlight
ABSTRACT:
SUBMITTER: Overton HA
PROVIDER: S-EPMC2268073 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Overton H A HA Fyfe M C T MC Reynet C C
British journal of pharmacology 20071126
GPR119 is a G protein-coupled receptor expressed predominantly in the pancreas (beta-cells) and gastrointestinal tract (enteroendocrine cells) in humans. De-orphanization of GPR119 has revealed two classes of possible endogenous ligands, viz., phospholipids and fatty acid amides. Of these, oleoylethanolamide (OEA) is one of the most active ligands tested so far. This fatty acid ethanolamide is of particular interest because of its known effects of reducing food intake and body weight gain when a ...[more]