Ontology highlight
ABSTRACT:
SUBMITTER: Jacquet K
PROVIDER: S-EPMC4887106 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Jacquet Karine K Fradet-Turcotte Amélie A Avvakumov Nikita N Lambert Jean-Philippe JP Roques Céline C Pandita Raj K RK Paquet Eric E Herst Pauline P Gingras Anne-Claude AC Pandita Tej K TK Legube Gaëlle G Doyon Yannick Y Durocher Daniel D Côté Jacques J
Molecular cell 20160501 3
The NuA4/TIP60 acetyltransferase complex is a key regulator of genome expression and stability. Here we identified MBTD1 as a stable subunit of the complex, and we reveal that, via a histone reader domain for H4K20me1/2, MBTD1 allows TIP60 to associate with specific gene promoters and to promote the repair of DNA double-strand breaks by homologous recombination. It was previously suggested that TIP60-dependent acetylation of H4 regulates binding of the non-homologous end joining factor 53BP1, wh ...[more]