Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC7005904 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wang Jiajia J He Hanqing H Chen Binbin B Jiang Guixing G Cao Liping L Jiang Haiping H Zhang Guofei G Chen Jianxiang J Huang Jun J Yang Bing B Zhou Chun C Liu Ting T
Nature communications 20200207 1
The XPF-ERCC1 heterodimer is a structure-specific endonuclease that is essential for nucleotide excision repair (NER) and interstrand crosslink (ICL) repair in mammalian cells. However, whether and how XPF binding to ERCC1 is regulated has not yet been established. Here, we show that TIP60, also known as KAT5, a haplo-insufficient tumor suppressor, directly acetylates XPF at Lys911 following UV irradiation or treatment with mitomycin C and that this acetylation is required for XPF-ERCC1 complex ...[more]