Ontology highlight
ABSTRACT:
SUBMITTER: Di Girolamo D
PROVIDER: S-EPMC4887175 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Di Girolamo Daniela D Ambrosio Raffaele R De Stefano Maria A MA Mancino Giuseppina G Porcelli Tommaso T Luongo Cristina C Di Cicco Emery E Scalia Giulia G Vecchio Luigi Del LD Colao Annamaria A Dlugosz Andrzej A AA Missero Caterina C Salvatore Domenico D Dentice Monica M
The Journal of clinical investigation 20160509 6
The thyroid hormone-inactivating (TH-inactivating) enzyme type 3 iodothyronine deiodinase (D3) is an oncofetal protein that is rarely expressed in adult life but has been shown to be reactivated in the context of proliferation and neoplasms. D3 terminates TH action within the tumor microenvironment, thereby enhancing cancer cell proliferation. However, the pathological role of D3 and the contribution of TH metabolism in cancer have yet to be fully explored. Here, we describe a reciprocal regulat ...[more]