Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population.
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SUBMITTER: Prakash J
PROVIDER: S-EPMC4888173 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population.
Prakash Jai J Mittal Balraj B Awasthi Shally S Srivastava Neena N
Iranian journal of public health 20160401 4
<h4>Background</h4>Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene -243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes.<h4>Methods</h4>Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method ...[more]
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