Dataset Information

Vascular endothelial growth factor C complements the ability of positron emission tomography to predict nodal disease in lung cancer.

ABSTRACT:

Objective

Vascular endothelial growth factors (VEGFs) C and D are biologically rational markers of nodal disease that could improve the accuracy of lung cancer staging. We hypothesized that these biomarkers would improve the ability of positron emission tomography (PET) to predict nodal disease among patients with suspected or confirmed non-small cell lung cancer (NSCLC).

Methods

A cross-sectional study (2010-2013) was performed of patients prospectively enrolled in a lung nodule biorepository, staged by computed tomography (CT) and PET, and who underwent pathologic nodal evaluation. Enzyme-linked immunosorbent assay was used to measure biomarker levels in plasma from blood drawn before anesthesia. Likelihood ratio testing was used to compare the following logistic regression prediction models: ModelPET, ModelPET/VEGF-C, ModelPET/VEGF-D, and ModelPET/VEGF-C/VEGF-D. To account for 5 planned pairwise comparisons, P values <.01 were considered significant.

Results

Among 62 patients (median age, 67 years; 48% men; 87% white; and 84% NSCLC), 58% had fluorodeoxyglucose uptake in hilar and/or mediastinal lymph nodes. The prevalence of pathologically confirmed lymph node metastases was 40%. Comparisons of prediction models revealed the following: ModelPET/VEGF-C versus ModelPET (P = .0069), ModelPET/VEGF-D versus ModelPET (P = .1886), ModelPET/VEGF-C/VEGF-D versus ModelPET (P = .0146), ModelPET/VEGF-C/VEGF-D versus ModelPET/VEGF-C (P = .2818), and ModelPET/VEGF-C/VEGF-D versus ModelPET/VEGF-D (P = .0095). In ModelPET/VEGF-C, higher VEGF-C levels were associated with an increased risk of nodal disease (odds ratio, 2.96; 95% confidence interval, 1.26-6.90).

Conclusions

Plasma levels of VEGF-C complemented the ability of PET to predict nodal disease among patients with suspected or confirmed NSCLC. VEGF-D did not improve prediction.

SUBMITTER: Farjah F

PROVIDER: S-EPMC4889434 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Publications

Vascular endothelial growth factor C complements the ability of positron emission tomography to predict nodal disease in lung cancer.

Farjah Farhood F Madtes David K DK Wood Douglas E DE Flum David R DR Zadworny Megan E ME Waworuntu Rachel R Hwang Billanna B Mulligan Michael S MS

The Journal of thoracic and cardiovascular surgery 20150806 4

<h4>Objective</h4>Vascular endothelial growth factors (VEGFs) C and D are biologically rational markers of nodal disease that could improve the accuracy of lung cancer staging. We hypothesized that these biomarkers would improve the ability of positron emission tomography (PET) to predict nodal disease among patients with suspected or confirmed non-small cell lung cancer (NSCLC).<h4>Methods</h4>A cross-sectional study (2010-2013) was performed of patients prospectively enrolled in a lung nodule ...[more]

PMID: 26320776

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Dataset Information

Vascular endothelial growth factor C complements the ability of positron emission tomography to predict nodal disease in lung cancer.

Objective

Methods

Results

Conclusions

Publications

Vascular endothelial growth factor C complements the ability of positron emission tomography to predict nodal disease in lung cancer.

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