Ontology highlight
ABSTRACT:
SUBMITTER: Claps G
PROVIDER: S-EPMC4889472 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Claps Giuseppina G Cheli Yann Y Zhang Tongwu T Scortegagna Marzia M Lau Eric E Kim Hyungsoo H Qi Jianfei J Li Jian-Liang JL James Brian B Dzung Andreas A Levesque Mitchell P MP Dummer Reinhard R Hayward Nicholas K NK Bosenberg Marcus M Brown Kevin M KM Ronai Ze'ev A ZA
Cell reports 20160519 9
Melanoma is one of the most lethal cutaneous malignancies, characterized by chemoresistance and a striking propensity to metastasize. The transcription factor ATF2 elicits oncogenic activities in melanoma, and its inhibition attenuates melanoma development. Here, we show that expression of a transcriptionally inactive form of Atf2 (Atf2(Δ8,9)) promotes development of melanoma in mouse models. Atf2(Δ8,9)-driven tumors show enhanced pigmentation, immune infiltration, and metastatic propensity. Sim ...[more]