Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4891041 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Zhang Zubin Z Mao Hongwu H Du Xiaolin X Zhu Jingyu J Xu Yujia Y Wang Siyu S Xu Xin X Ji Peng P Yu Yang Y Cao Biyin B Han Kunkun K Hou Tingjun T Xu Zhuan Z Kong Yan Y Jiang Gaofeng G Tang Xiaowen X Qiao Chunhua C Mao Xinliang X
Oncotarget 20160201 8
The oncogenic STAT3 signaling pathway is emerging as a promising target for the treatment of multiple myeloma (MM). In the present study, we identified a novel STAT3 inhibitor SC99 in a target-based high throughput screen. SC99 inhibited JAK2-STAT3 activation but had no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src that are in association with STAT3 signaling pathway. Furthermore, SC99 downregulated the expression of STAT3-modulated genes, includin ...[more]