Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC4096847 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Chen Haijun H Yang Zhengduo Z Ding Chunyong C Xiong Ailian A Wild Christopher C Wang Lili L Ye Na N Cai Guoshuai G Flores Rudolfo M RM Ding Ye Y Shen Qiang Q Zhou Jia J
European journal of medicinal chemistry 20140522
In a continuing effort to develop orally bioavailable small-molecule STAT3 inhibitors as potential therapeutic agents for human cancer, a series of novel diversified analogues based on our identified lead compound HJC0149 (1) (5-chloro-N-(1,1-dioxo-1H-1λ(6)-benzo[b]thiophen-6-yl)-2-hydroxybenzamide, Eur. J. Med. Chem. 2013, 62, 498-507) have been rationally designed, synthesized, and pharmacologically evaluated. Molecular docking studies and biological characterization supported our earlier find ...[more]