Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia.
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SUBMITTER: Clinkenbeard EL
PROVIDER: S-EPMC4891276 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia.
Clinkenbeard Erica L EL Cass Taryn A TA Ni Pu P Hum Julia M JM Bellido Teresita T Allen Matthew R MR White Kenneth E KE
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20160304 6
The transgenic and knockout (KO) animals involving Fgf23 have been highly informative in defining novel aspects of mineral metabolism, but are limited by shortened lifespan, inability of spatial/temporal FGF23 control, and infertility of the global KO. To more finely test the role of systemic and genetic influences in FGF23 production, a mouse was developed that carried a floxed ("f")-Fgf23 allele (exon 2 floxed) which demonstrated in vivo recombination when bred to global-Cre transgenic mice (e ...[more]
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