Dataset Information
Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study.
Ontology highlight
ABSTRACT: Background
A protective effect of tricyclic antidepressants (TCAs) against gliomas has been suggested by a small number of studies. We investigated this putative association in a nationwide setting.Methods
Using a case-control design, we identified all patients with histologically verified glioma (cases) in Denmark between 2000 and 2012 and matched these 1?:?20 to population controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) for glioma associated with long-term (?3 years) use of TCAs. Similar analyses were performed for selective serotonin reuptake inhibitors (SSRIs).Results
We identified 3767 glioma cases and 75?340 population controls. Long-term use of TCAs was inversely associated with risk of glioma (OR 0.72, 95% CI: 0.41-1.25). Long-term SSRI use was not associated with glioma risk (OR 0.93, 95% CI: 0.75-1.16).Conclusions
Our study indicated that long-term use of TCAs may be associated with a reduced risk of glioma, however, the statistical precision was limited. A similar pattern was not observed for use of SSRIs.
SUBMITTER: Pottegard A
PROVIDER: S-EPMC4891498 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study.
British journal of cancer 20160426 11
<h4>Background</h4>A protective effect of tricyclic antidepressants (TCAs) against gliomas has been suggested by a small number of studies. We investigated this putative association in a nationwide setting.<h4>Methods</h4>Using a case-control design, we identified all patients with histologically verified glioma (cases) in Denmark between 2000 and 2012 and matched these 1 : 20 to population controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) for glioma assoc ...[more]
