Dataset Information

Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative.

ABSTRACT:

Background

Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.

Methods

The DII was calculated from a baseline food frequency questionnaire in 122?788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference.

Results

The DII was not associated with incidence of overall breast cancer (HRQ5vsQ1, 0.99; 95% CI, 0.91-1.07; Ptrend=0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HRQ5vsQ1, 1.33; 95% CI, 1.01-1.76; Ptrend=0.03).

Conclusions

Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.

SUBMITTER: Tabung FK

PROVIDER: S-EPMC4891517 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Publications

Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative.

Tabung Fred K FK Steck Susan E SE Liese Angela D AD Zhang Jiajia J Ma Yunsheng Y Caan Bette B Chlebowski Rowan T RT Freudenheim Jo L JL Hou Lifang L Mossavar-Rahmani Yasmin Y Shivappa Nitin N Vitolins Mara Z MZ Wactawski-Wende Jean J Ockene Judith K JK Hébert James R JR

British journal of cancer 20160421 11

<h4>Background</h4>Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.<h4>Methods</h4>The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 ...[more]

PMID: 27100730

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Dataset Information

Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative.

Background

Methods

Results

Conclusions

Publications

Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative.

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