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Social relationships, inflammation markers, and breast cancer incidence in the Women's Health Initiative.

ABSTRACT: OBJECTIVES:Previous research has reported associations between social relationships and carcinogenesis. Inflammation is a potential mediator of these associations. To clarify these links for one tumor site, we examined associations between social relationships, circulating inflammation markers, and breast cancer incidence. MATERIALS AND METHODS:Among 132,262 participants from the prospective Women's Health Initiative, we used linear and logistic regression to evaluate associations between social relationship characteristics (social support, social strain, social network size) and inflammation markers of C-reactive protein (CRP) and white blood cell count (WBC). Cox regression was used to evaluate associations between inflammation markers and breast cancer incidence, as well as associations between social relationship characteristics and breast cancer incidence with and without adjustment for inflammation markers. RESULTS:Larger social networks were associated with lower continuous CRP (beta?=?-0.22, 95% CI -0.36, -0.08) and WBC (beta?=?-0.23, 95% CI -0.31, -0.16). Greater social strain was associated with higher continuous CRP (beta?=?0.24, 95% CI 0.14, 0.33) and WBC (beta?=?0.09, 95% CI 0.04, 0.14). When WBC was dichotomized at 10,000?cells/uL, high WBC was associated with greater hazards of in situ breast cancer (HR?=?1.65, 95% CI 1.17, 2.33) but not invasive breast cancer. Social relationship characteristics were not associated with incidence of invasive or in situ breast cancer. CONCLUSION:Larger social networks were associated with lower inflammation and greater social strain was associated with higher inflammation. Higher inflammation might be associated with development of in situ breast cancer, but this appeared to be due to factors other than social relationships.

SUBMITTER: Busch EL

PROVIDER: S-EPMC5936641 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Social relationships, inflammation markers, and breast cancer incidence in the Women's Health Initiative.

Busch Evan L EL Whitsel Eric A EA Kroenke Candyce H CH Yang Yang C YC

Breast (Edinburgh, Scotland) 20180331

<h4>Objectives</h4>Previous research has reported associations between social relationships and carcinogenesis. Inflammation is a potential mediator of these associations. To clarify these links for one tumor site, we examined associations between social relationships, circulating inflammation markers, and breast cancer incidence.<h4>Materials and methods</h4>Among 132,262 participants from the prospective Women's Health Initiative, we used linear and logistic regression to evaluate associations ...[more]

PMID: 29614476

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Project description:PurposeThis study aimed to evaluate racial/ethnic differences in lung cancer incidence and mortality in the Women's Health Initiative Study, a longitudinal prospective cohort evaluation of postmenopausal women recruited from 40 clinical centers.MethodsLung cancer diagnoses were centrally adjudicated by pathology review. Baseline survey questionnaires collected sociodemographic and health information. Logistic regression models estimated incidence and mortality odds by race/ethnicity adjusted for age, education, calcium/vitamin D, body mass index, smoking (status, age at start, duration, and pack-years), alcohol, family history, oral contraceptive, hormones, physical activity, and diet.ResultsThe cohort included 129,951 women--108,487 (83%) non-Hispanic white (NHW); 10,892 (8%) non-Hispanic black (NHB); 4,882 (4%) Hispanic; 3,696 (3%) Asian/Pacific Islander (API); 534 (< 1%) American Indian/Alaskan Native; and 1,994 (1%) other. In unadjusted models, Hispanics had 66% lower odds of lung cancer compared with NHW (odds ratio [OR], 0.34; 95% CI, 0.2 to 0.5), followed by API (OR, 0.45; 95% CI, 0.27 to 0.75) and NHB (OR, 0.75; 95% CI, 0.59 to 0.95). In fully adjusted multivariable models, the decreased lung cancer risk for Hispanic compared with NHW women attenuated to the null (OR, 0.59; 95% CI, 0.35 to 0.99). In unadjusted models Hispanic and API women had decreased risk of death compared with NHW women (OR, 0.30 [95% CI, 0.15 to 0.62] and 0.34 [95% CI, 0.16 to 0.75, respectively); however, no racial/ethnic differences were found in risk of lung cancer death in fully adjusted models.ConclusionDifferences in lung cancer incidence and mortality are associated with sociodemographic, clinical, and behavioral factors. These findings suggest modifiable exposures and behaviors may contribute to differences in incidence of and mortality by race/ethnicity for postmenopausal women. Interventions focused on these factors may reduce racial/ethnic differences in lung cancer incidence and mortality.

Dataset Information

Social relationships, inflammation markers, and breast cancer incidence in the Women's Health Initiative.

Publications

Social relationships, inflammation markers, and breast cancer incidence in the Women's Health Initiative.

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