Ontology highlight
ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC4891981 | biostudies-literature | 2015 Nov-Dec
REPOSITORIES: biostudies-literature
Xu Liang L Wang Wei W Chong Jenny J Shin Ji Hyun JH Xu Jun J Wang Dong D
Critical reviews in biochemistry and molecular biology 20150922 6
Accurate genetic information transfer is essential for life. As a key enzyme involved in the first step of gene expression, RNA polymerase II (Pol II) must maintain high transcriptional fidelity while it reads along DNA template and synthesizes RNA transcript in a stepwise manner during transcription elongation. DNA lesions or modifications may lead to significant changes in transcriptional fidelity or transcription elongation dynamics. In this review, we will summarize recent progress toward un ...[more]