Ontology highlight
ABSTRACT:
SUBMITTER: Estepp JH
PROVIDER: S-EPMC4892120 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Estepp Jeremie H JH Melloni Chiara C Thornburg Courtney D CD Wiczling Paweł P Rogers Zora Z Rothman Jennifer A JA Green Nancy S NS Liem Robert R Brandow Amanda M AM Crary Shelley E SE Howard Thomas H TH Morris Maurine H MH Lewandowski Andrew A Garg Uttam U Jusko William J WJ Neville Kathleen A KA
Journal of clinical pharmacology 20151015 3
Hydroxyurea (HU) is a crucial therapy for children with sickle cell anemia, but its off-label use is a barrier to widespread acceptance. We found HU exposure is not significantly altered by liquid vs capsule formulation, and weight-based dosing schemes provide consistent exposure. HU is recommended for all children starting as young as 9 months of age with sickle cell anemia (SCA; HbSS and HbSβspan(0) thalassemia); however; a paucity of pediatric data exists regarding the pharmacokinetics (PK) o ...[more]