Ontology highlight
ABSTRACT:
SUBMITTER: Ma L
PROVIDER: S-EPMC4892293 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ma Liang L Wang Taijin T Shi Min M Ye Haoyu H
Drug design, development and therapy 20160530
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-mediated transcription factor playing key roles in glucose and lipid homeostasis, and PPARγ ligands possess therapeutic potential in these as well as other areas. In this study, a series of phenylthiazole acids have been synthesized and evaluated for agonistic activity by a convenient fluorescence polarization-based PPARγ ligand screening assay. Compound 4t, as a potential PPARγ agonist with half maximal effective concentration ...[more]