Unknown

Dataset Information

0

Association of the Neutrophil-to-Lymphocyte Ratio with Lung Function and Exacerbations in Patients with Chronic Obstructive Pulmonary Disease.


ABSTRACT:

Background

The ratio of neutrophils to lymphocytes (NLR) is a widely available marker of inflammation. Several types of inflammatory cells and mediators have been found to be involved in the progression of chronic obstructive pulmonary disease (COPD). We sought to evaluate the association of the NLR with severity of airflow limitation and disease exacerbations in a COPD population.

Methods

We analyzed 885 patients from the Korean COPD Subtype Study cohort that recruited subjects with COPD from 44 referral hospitals. We determined the relationship of NLR levels to severity of lung function using a linear regression model. In addition, we analyzed the experiences of COPD exacerbation according to the NLR quartiles.

Results

NLR levels were inversely associated with severity of airflow limitation as measured by FEV1% predicted and absolute values after adjustments for age, gender, body mass index, pack-years of smoking, and the use of inhaled corticosteroid (P<0.001, respectively). In the multivariate binary regression model, the NLR 4th quartile (vs. 1st quartile) was found to be a significant predictor of exacerbations during 1-year follow-up (OR = 2.05, 95% CI = 1.03 to 4.06, P = 0.041). Adding an NLR to FEV1 significantly improved prediction for exacerbations during 1-year follow-up as measured by the net reclassification improvement (NRI = 7.8%, P = 0.032) and the integrated discrimination improvement (IDI = 0.014, P = 0.021).

Conclusions

The NLR showed a significant inverse relationship to airflow limitation and was a prognostic marker for future exacerbations in patients with COPD.

SUBMITTER: Lee H 

PROVIDER: S-EPMC4892618 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association of the Neutrophil-to-Lymphocyte Ratio with Lung Function and Exacerbations in Patients with Chronic Obstructive Pulmonary Disease.

Lee Heock H   Um Soo-Jung SJ   Kim Yun Seong YS   Kim Deog Kyeom DK   Jang An Soo AS   Choi Hye Sook HS   Kim Yee Hyung YH   Kim Tae Eun TE   Yoo Kwang Ha KH   Jung Ki-Suck KS  

PloS one 20160603 6


<h4>Background</h4>The ratio of neutrophils to lymphocytes (NLR) is a widely available marker of inflammation. Several types of inflammatory cells and mediators have been found to be involved in the progression of chronic obstructive pulmonary disease (COPD). We sought to evaluate the association of the NLR with severity of airflow limitation and disease exacerbations in a COPD population.<h4>Methods</h4>We analyzed 885 patients from the Korean COPD Subtype Study cohort that recruited subjects w  ...[more]

Similar Datasets

| S-EPMC6641779 | biostudies-literature
| S-EPMC7365378 | biostudies-literature
| S-EPMC7331605 | biostudies-literature
2021-03-21 | GSE112165 | GEO
| S-EPMC7358911 | biostudies-literature
| S-EPMC6517133 | biostudies-literature
| S-EPMC4407303 | biostudies-literature
| S-EPMC5674213 | biostudies-literature
| S-EPMC7454017 | biostudies-literature