Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.
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ABSTRACT:
SUBMITTER: Liu CW
PROVIDER: S-EPMC4893790 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
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Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.
Liu Chih-Wei CW Atkinson Mark A MA Zhang Qibin Q
Proteomics 20160413 9
Type 1 diabetes (T1D) is an autoimmune disorder resulting from a self-destruction of pancreatic islet beta cells. The complete proteome of the human pancreas, where both the dysfunctional beta cells and their proximal environment co-exist, remains unknown. Here, we used TMT10-based isobaric labeling and multidimensional LC-MS/MS to quantitatively profile the differences between pancreatic head region tissues from T1D (N = 5) and healthy subjects (N = 5). Among the 5357 (1% false discovery rate) ...[more]
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