Ontology highlight
ABSTRACT:
SUBMITTER: Sun Z
PROVIDER: S-EPMC4894433 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Sun Zhiqiang Z Tan Hui Yin HY Bianco Piero R PR Lyubchenko Yuri L YL
Scientific reports 20150429
The RecG DNA helicase a key player in stalled replication fork rescue. The single-stranded DNA binding protein (SSB) participates in this process, but its role in the interaction of RecG with the fork remains unclear. We used atomic force microscopy (AFM) to visualize the interaction of RecG with a fork DNA in the presence of SSB. We discovered that SSB enhances RecG loading efficiency onto the DNA fork by threefold. Additionally, SSB interacts with RecG leading to the RecG remodeling. As a resu ...[more]