Ontology highlight
ABSTRACT:
SUBMITTER: Ubezio B
PROVIDER: S-EPMC4894757 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Ubezio Benedetta B Blanco Raquel Agudo RA Geudens Ilse I Stanchi Fabio F Mathivet Thomas T Jones Martin L ML Ragab Anan A Bentley Katie K Gerhardt Holger H
eLife 20160413
Formation of a regularly branched blood vessel network is crucial in development and physiology. Here we show that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse retina in vivo and in correlation with dynamic cell movement in mouse embryonic stem cell-derived sprouting assays. We also find that sprout elongation and branching associates with a highly differential phase pattern of Dll4 between endothelial cells. Stimulation ...[more]