Ontology highlight
ABSTRACT:
SUBMITTER: Malinauskaite L
PROVIDER: S-EPMC4894957 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Nature communications 20160525
Bacterial members of the neurotransmitter:sodium symporter (NSS) family perform Na(+)-dependent amino-acid uptake and extrude H(+) in return. Previous NSS structures represent intermediates of Na(+)/substrate binding or intracellular release, but not the inward-to-outward return transition. Here we report crystal structures of Aquifex aeolicus LeuT in an outward-oriented, Na(+)- and substrate-free state likely to be H(+)-occluded. We find a remarkable rotation of the conserved Leu25 into the emp ...[more]