Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4894967 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Wang Xuejuan X Chu Huanyu H Lv Mengjuan M Zhang Zhihui Z Qiu Shuwan S Liu Haiyan H Shen Xuetong X Wang Weiwu W Cai Gang G
Nature communications 20160527
The ataxia-telangiectasia mutated (ATM) protein is an apical kinase that orchestrates the multifaceted DNA-damage response. Normally, ATM kinase is in an inactive, homodimer form and is transformed into monomers upon activation. Besides a conserved kinase domain at the C terminus, ATM contains three other structural modules, referred to as FAT, FATC and N-terminal helical solenoid. Here we report the first cryo-EM structure of ATM kinase, which is an intact homodimeric ATM/Tel1 from Schizosaccha ...[more]