Ontology highlight
ABSTRACT:
SUBMITTER: Lau WC
PROVIDER: S-EPMC4889239 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Cell cycle (Georgetown, Tex.) 20160101 8
DNA-double strand breaks activate the serine/threonine protein kinase ataxia-telangiectasia mutated (ATM) to initiate DNA damage signal transduction. This activation process involves autophosphorylation and dissociation of inert ATM dimers into monomers that are catalytically active. Using single-particle electron microscopy (EM), we determined the structure of dimeric ATM in its resting state. The EM map could accommodate the crystal structure of the N-terminal truncated mammalian target of rap ...[more]