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Semisynthetic studies on the manzamine alkaloids.

ABSTRACT: Chemical transformation studies were conducted on (-)-8-hydroxymanzamine A ( 1), (-)-manzamine F ( 2), manzamine A ( 3), and (+)-8-hydroxymanzamine A ( 4), isolated from Indo-Pacific Acanthostrongylophora sponges. Thirteen new semisynthetic manzamine derivatives, including four Delta (34,35) manzamines ( 5, 6, 8, and 9) and the unprecedented manzamine derivative 17, are reported. The potent in vitro activities of the obtained semisynthetic manzamines against activated brain microglia and the AIDS opportunistic infection pathogen Mycobacterium tuberculosis are presented.

SUBMITTER: Sayed KA

PROVIDER: S-EPMC4895205 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Semisynthetic studies on the manzamine alkaloids.

Sayed Khalid A El KA Khalil Ashraf A AA Yousaf Muhammad M Labadie Guillermo G Kumar Gundluru M GM Franzblau Scott G SG Mayer Alejandro M S AM Avery Mitchell A MA Hamann Mark T MT

Journal of natural products 20080117 3

Chemical transformation studies were conducted on (-)-8-hydroxymanzamine A ( 1), (-)-manzamine F ( 2), manzamine A ( 3), and (+)-8-hydroxymanzamine A ( 4), isolated from Indo-Pacific Acanthostrongylophora sponges. Thirteen new semisynthetic manzamine derivatives, including four Delta (34,35) manzamines ( 5, 6, 8, and 9) and the unprecedented manzamine derivative 17, are reported. The potent in vitro activities of the obtained semisynthetic manzamines against activated brain microglia and the AID ...[more]

PMID: 18198837

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