Ontology highlight
ABSTRACT:
SUBMITTER: Sayed KA
PROVIDER: S-EPMC4895205 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Sayed Khalid A El KA Khalil Ashraf A AA Yousaf Muhammad M Labadie Guillermo G Kumar Gundluru M GM Franzblau Scott G SG Mayer Alejandro M S AM Avery Mitchell A MA Hamann Mark T MT
Journal of natural products 20080117 3
Chemical transformation studies were conducted on (-)-8-hydroxymanzamine A ( 1), (-)-manzamine F ( 2), manzamine A ( 3), and (+)-8-hydroxymanzamine A ( 4), isolated from Indo-Pacific Acanthostrongylophora sponges. Thirteen new semisynthetic manzamine derivatives, including four Delta (34,35) manzamines ( 5, 6, 8, and 9) and the unprecedented manzamine derivative 17, are reported. The potent in vitro activities of the obtained semisynthetic manzamines against activated brain microglia and the AID ...[more]