Ontology highlight
ABSTRACT:
SUBMITTER: Shilabin AG
PROVIDER: S-EPMC4918903 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Shilabin Abbas Gholipour AG Kasanah Noer N Tekwani Babu L BL Hamann Mark T MT
Journal of natural products 20080704 7
The manzamines represent a class of marine natural products that show considerable promise in the control of malaria but generate GI distress in rodents when administered orally in high doses. In an effort to generate manzamine prodrugs with improved antimalarial activity and reduced GI toxicity, we prepared acetylated 8-hydroxymanzamine A analogues including 8-acetoxymanzamine A (3) and 8,12-diacetoxymanzamine A (4), and 8-methoxymanzamine A (5) beginning with 8-hydroxymanzamine A (2). The semi ...[more]