Ontology highlight
ABSTRACT:
SUBMITTER: Campos M
PROVIDER: S-EPMC4895609 | biostudies-literature | 2014 Nov-Dec
REPOSITORIES: biostudies-literature
Campos M M Kool M M J MM Daminet S S Ducatelle R R Rutteman G G Kooistra H S HS Galac S S Mol J A JA
Journal of veterinary internal medicine 20140917 6
<h4>Background</h4>Information on the genetic events leading to thyroid cancer in dogs is lacking.<h4>Hypothesis/objectives</h4>Upregulation of the PI3K/Akt pathway has an important role in the tumorigenesis of thyroid carcinoma in dogs.<h4>Animals</h4>Fifty-nine dogs with thyroid carcinoma and 10 healthy controls.<h4>Methods</h4>Quantitative RT-PCR was performed for VEGFR-1, VEGFR-2, EGFR, PIK3CA, PIK3CB, PDPK1, PTEN, AKT1, AKT2, COX-2, and CALCA. Mutation analysis was performed for known hotsp ...[more]