Tenascin-C drives persistence of organ fibrosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharyya S
PROVIDER: S-EPMC4895803 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Tenascin-C drives persistence of organ fibrosis.
Bhattacharyya Swati S Wang Wenxia W Morales-Nebreda Luisa L Feng Gang G Wu Minghua M Zhou Xiaodong X Lafyatis Robert R Lee Jungwha J Hinchcliff Monique M Feghali-Bostwick Carol C Lakota Katja K Budinger G R Scott GR Raparia Kirtee K Tamaki Zenshiro Z Varga John J
Nature communications 20160603
The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc) are not known but emerging evidence implicates toll-like receptors (TLRs) in the pathogenesis of SSc. Here we show the expression, mechanism of action and pathogenic role of endogenous TLR activators in skin from patients with SSc, skin fibroblasts, and in mouse models of organ fibrosis. Levels of tenascin-C are elevated in SSc skin biopsy samples, and serum and SSc fibroblasts, and in fibrotic skin tis ...[more]
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