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Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells.

ABSTRACT: In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genetic plasmids and reassortant viruses, we here demonstrate that a homologous lineage PB1-PB2 pair exhibits better compatibility than a heterologous one and that the lineage relationship between PB1 and HA is more important for viral replication than that between PB2 and HA. However, co-adaptation of PB1-PB2-HA genes appears to be affected by complete gene constellation.

SUBMITTER: Kim JI

PROVIDER: S-EPMC4897687 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells.

Kim Jin Il JI Lee Ilseob I Park Sehee S Bae Joon-Yong JY Yoo Kirim K Lemey Philippe P Park Mee Sook MS Song Jin-Won JW Kee Sun-Ho SH Song Ki-Joon KJ Park Man-Seong MS

Scientific reports 20160608

In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genetic plasmids and reassortant viruses, we here demonstrate that a homologous lineage PB1-PB2 pair exhibits better compatibility than a heterologous one and that the lineage relationship between PB1 and ...[more]

PMID: 27270757

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