Increased airway glucose increases airway bacterial load in hyperglycaemia.
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ABSTRACT:
SUBMITTER: Gill SK
PROVIDER: S-EPMC4897689 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Increased airway glucose increases airway bacterial load in hyperglycaemia.
Gill Simren K SK Hui Kailyn K Farne Hugo H Garnett James P JP Baines Deborah L DL Moore Luke S P LS Holmes Alison H AH Filloux Alain A Tregoning John S JS
Scientific reports 20160608
Diabetes is associated with increased frequency of hospitalization due to bacterial lung infection. We hypothesize that increased airway glucose caused by hyperglycaemia leads to increased bacterial loads. In critical care patients, we observed that respiratory tract bacterial colonisation is significantly more likely when blood glucose is high. We engineered mutants in genes affecting glucose uptake and metabolism (oprB, gltK, gtrS and glk) in Pseudomonas aeruginosa, strain PAO1. These mutants ...[more]
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