Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Drenberg CD
PROVIDER: S-EPMC4898266 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia.
Drenberg C D CD Paugh S W SW Pounds S B SB Shi L L Orwick S J SJ Li L L Hu S S Gibson A A AA Ribeiro R C RC Rubnitz J E JE Evans W E WE Sparreboom A A Baker S D SD
Clinical pharmacology and therapeutics 20160220 6
Using broad interrogation of clinically relevant drug absorption, distribution, metabolism, and excretion (ADME) genes on the DMET platform, we identified a genetic variant in SLCO1B1 (rs2291075; c.597C>T), encoding the transporter OATP1B1, associated with event-free (P = 0.006, hazard ratio = 1.74) and overall survival (P = 0.012, hazard ratio = 1.85) in children with de novo acute myeloid leukemia (AML). Lack of SLCO1B1 expression in leukemic blasts suggested the association might be due to an ...[more]
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