Ontology highlight
ABSTRACT:
SUBMITTER: Cherepanova OA
PROVIDER: S-EPMC4899256 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cherepanova Olga A OA Gomez Delphine D Shankman Laura S LS Swiatlowska Pamela P Williams Jason J Sarmento Olga F OF Alencar Gabriel F GF Hess Daniel L DL Bevard Melissa H MH Greene Elizabeth S ES Murgai Meera M Turner Stephen D SD Geng Yong-Jian YJ Bekiranov Stefan S Connelly Jessica J JJ Tomilin Alexey A Owens Gary K GK
Nature medicine 20160516 6
Although somatic cell activation of the embryonic stem cell (ESC) pluripotency factor OCT4 has been reported, this previous work has been controversial and has not demonstrated a functional role for OCT4 in somatic cells. Here we demonstrate that smooth muscle cell (SMC)-specific conditional knockout of Oct4 in Apoe(-/-) mice resulted in increased lesion size and changes in lesion composition that are consistent with decreased plaque stability, including a thinner fibrous cap, increased necrotic ...[more]