Foci of cyclin A2 interact with actin and RhoA in mitosis.
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ABSTRACT:
SUBMITTER: Loukil A
PROVIDER: S-EPMC4899731 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Foci of cyclin A2 interact with actin and RhoA in mitosis.
Loukil Abdelhalim A Izard Fanny F Georgieva Mariya M Mashayekhan Shaereh S Blanchard Jean-Marie JM Parmeggiani Andrea A Peter Marion M
Scientific reports 20160609
Cyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis depends primarily on the ubiquitin-proteasome system (UPS), while autophagy also contributes. However, a fraction of cyclin A2 persists beyond metaphase. In this work, we focus on cyclin A2-rich foci detected in mitosis by high resolution imaging and analyse their movements. We demonstrate that cyclin A2 interacts with actin and RhoA during mitosis, and that cyclin A2 depletion induces a dramatic decrea ...[more]
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