Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC4899801 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Zhang Wei W Xue Deting D Yin Houfa H Wang Shengdong S Li Chao C Chen Erman E Hu Dongcai D Tao Yiqing Y Yu Jiawei J Zheng Qiang Q Gao Xiang X Pan Zhijun Z
Scientific reports 20160609
HSPA1A, which encodes cognate heat shock protein 70, plays important roles in various cellular metabolic pathways. To investigate its effects on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), its expression level was compared between undifferentiated and differentiated BMSCs. Rat HSPA1A overexpression in BMSCs increased osteoblast-specific gene expression, alkaline phosphatase activity, and mineral deposition in vitro. Moreover, it upregulated β-catenin and downregulat ...[more]