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Enantioselective C-H Olefination of ?-Hydroxy and ?-Amino Phenylacetic Acids by Kinetic Resolution.


ABSTRACT: Significant progress has been made in the past decade regarding the development of enantioselective C-H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C-H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)-catalyzed enantioselective C-H activation and C-C bond formation, thus significantly expanding the scope of enantioselective C-H activation reactions.

SUBMITTER: Xiao KJ 

PROVIDER: S-EPMC4899946 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Enantioselective C-H Olefination of α-Hydroxy and α-Amino Phenylacetic Acids by Kinetic Resolution.

Xiao Kai-Jiong KJ   Chu Ling L   Yu Jin-Quan JQ  

Angewandte Chemie (International ed. in English) 20160122 8


Significant progress has been made in the past decade regarding the development of enantioselective C-H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C-H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)-catalyzed enantioselective C-H activation and C-C bond formation, thus significantly expanding the scope of enantioselective C-H activation reactions  ...[more]

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