Ontology highlight
ABSTRACT:
SUBMITTER: Choi JM
PROVIDER: S-EPMC4900293 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Choi Jai Min JM Rotimi Odunayo O OO O'Carroll Simon J SJ Nicholson Louise F B LF
F1000Research 20160303
Systemic inflammation is associated with neurodegeneration, with elevated interleukin-6 (IL-6) in particular being correlated with an increased risk of dementia. The brain endothelial cells of the blood brain barrier (BBB) serve as the interface between the systemic circulation and the brain microenvironment and are therefore likely to be a key player in the development of neuropathology associated with systemic inflammation. Endothelial cells are known to require soluble IL-6 receptor (sIL-6R) ...[more]