Ontology highlight
ABSTRACT:
SUBMITTER: Djaout K
PROVIDER: S-EPMC4901301 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Djaout Kamel K Singh Vinayak V Boum Yap Y Katawera Victoria V Becker Hubert F HF Bush Natassja G NG Hearnshaw Stephen J SJ Pritchard Jennifer E JE Bourbon Pauline P Madrid Peter B PB Maxwell Anthony A Mizrahi Valerie V Myllykallio Hannu H Ekins Sean S
Scientific reports 20160610
There is an urgent need to identify new treatments for tuberculosis (TB), a major infectious disease caused by Mycobacterium tuberculosis (Mtb), which results in 1.5 million deaths each year. We have targeted two essential enzymes in this organism that are promising for antibacterial therapy and reported to be inhibited by naphthoquinones. ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the human enzyme. DNA gyrase is a DNA topoisomerase present in ...[more]