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Bacterial thymidylate synthase with intein, group II Intron, and distinctive ThyX motifs.


ABSTRACT: The ThyX class of thymidylate synthases was previously characterized by a common ThyX motif, RHRX7S. We report bacterial ThyX sequences having distinctive ThyX motifs, suggesting a more general ThyX motif, R/THRX7-8S. One ThyX sequence has an intein in its ThyX motif that was shown to do protein splicing and a group II intron in its gene, suggesting a hot spot for these self-splicing mobile elements.

SUBMITTER: Liu XQ 

PROVIDER: S-EPMC515151 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature

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Bacterial thymidylate synthase with intein, group II Intron, and distinctive ThyX motifs.

Liu Xiang-Qin XQ   Yang Jing J  

Journal of bacteriology 20040901 18


The ThyX class of thymidylate synthases was previously characterized by a common ThyX motif, RHRX7S. We report bacterial ThyX sequences having distinctive ThyX motifs, suggesting a more general ThyX motif, R/THRX7-8S. One ThyX sequence has an intein in its ThyX motif that was shown to do protein splicing and a group II intron in its gene, suggesting a hot spot for these self-splicing mobile elements. ...[more]

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