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Antibacterial structure-activity relationship studies of several tricyclic sulfur-containing flavonoids.

ABSTRACT: A structure-activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have been synthesized by cyclocondensation of the corresponding 3-dithiocarbamic flavanones under acidic conditions. The influence of different halogen substituents on the antibacterial properties has been tested against Staphylococcus aureus and Escherichia coli. Amongst the N,N-dialkylamino-substituted flavonoids, those having an N,N-diethylamino moiety exhibited good to excellent antimicrobial properties against both pathogens. Fluorine-substituted flavonoids were found to be less active than those bearing other halogen atoms.

SUBMITTER: Bahrin LG

PROVIDER: S-EPMC4902053 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Antibacterial structure-activity relationship studies of several tricyclic sulfur-containing flavonoids.

Bahrin Lucian G LG Hopf Henning H Jones Peter G PG Sarbu Laura G LG Babii Cornelia C Mihai Alina C AC Stefan Marius M Birsa Lucian M LM

Beilstein journal of organic chemistry 20160523

A structure-activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have been synthesized by cyclocondensation of the corresponding 3-dithiocarbamic flavanones under acidic conditions. The influence of different halogen substituents on the antibacterial properties has been tested against Staphylococcus aureus and Escherichia coli. Amongst the N,N-dialkylamino-substituted flavonoids ...[more]

PMID: 27340492

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