Unknown

Dataset Information

0

Structure-activity relationship studies of the tricyclic indoline resistance-modifying agent.


ABSTRACT: Previously we discovered a tricyclic indoline, N-[2-(6-bromo-4-methylidene-2,3,4,4a,9,9a-hexahydro-1H-carbazol-4a-yl)ethyl]-4-chlorobenzene-1-sulfonamide (1, Of1), from bioinspired synthesis of a highly diverse polycyclic indoline alkaloid library, that selectively resensitizes methicillin-resistant Staphylococcus aureus strains to β-lactam antibiotics. Herein, we report a thorough structure-activity relationship investigation of 1, which identified regions of 1 that tolerate modifications without compromising activity and afforded the discovery of a more potent analogue with reduced mammalian toxicity.

SUBMITTER: Chang L 

PROVIDER: S-EPMC4018117 | biostudies-other | 2014 May

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4902053 | biostudies-literature
| S-EPMC4266428 | biostudies-literature
| S-EPMC4278651 | biostudies-literature
| S-EPMC3975045 | biostudies-literature
| S-EPMC5406294 | biostudies-literature
| S-EPMC3963473 | biostudies-literature
| S-EPMC5346993 | biostudies-literature
| S-EPMC5846039 | biostudies-literature
| S-EPMC9885930 | biostudies-literature
| S-EPMC3504033 | biostudies-literature