Ontology highlight
ABSTRACT:
SUBMITTER: Mikhalchenko OS
PROVIDER: S-EPMC4902074 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20160406
Conditions enabling the single-step preparative synthesis of chiral 4-fluoropolyhydro-2H-chromenes in good yields through a reaction between monoterpenoid alcohols with para-menthane skeleton and aldehydes were developed for the first time. The BF3·Et2O/H2O system is used both as a catalyst and as a fluorine source. The reaction can involve aliphatic aldehydes as well as aromatic aldehydes containing various acceptor and donor substituents. 4-Hydroxyhexahydro-2H-chromenes were demonstrated to be ...[more]