Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC6051884 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Yang Fei F Li Yangshan Y Floreancig Paul E PE Li Xiaoyan X Liu Lei L
Organic & biomolecular chemistry 20180701 28
An efficient copper-catalyzed cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes mediated by DDQ has been established. A protic additive, EtOH, proved to be crucial for harmonizing the oxidation with a subsequent alkynylation step by retaining the oxidation state of an oxocarbenium ion in the form of acetal. The CDC reaction exhibits a good substrate scope, with a range of terminal aryl- and alkyl alkynes being well tolerated. The copper-catalyzed alkynylation of 2H-chromene ace ...[more]