Ontology highlight
ABSTRACT:
SUBMITTER: Ossman R
PROVIDER: S-EPMC4902534 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Ossman Rime R Buob David D Hellmark Thomas T Brocheriou Isabelle I Peltier Julie J Tamouza Ryad R Dahan Karine K Hertig Alexandre A Rondeau Eric E Galichon Pierre P
Medicine 20160501 19
Antiglomerular basement membrane (GBM) disease is known as a super-acute proliferative glomerulonephritis caused by auto-antibodies targeting the NC1 domain of the α3 chain of type IV collagen.Here, we describe a case of atypical anti-GBM disease presenting as a dialysis-dependent acute renal failure with unusual mild glomerular involvement. We found that immunoglobulin G (IgG) deposits were restricted to the uncommon IgG2 and IgG4 subclasses, and that blood was positive for anti-GBM antibodies ...[more]