Ontology highlight
ABSTRACT:
SUBMITTER: Tai DJ
PROVIDER: S-EPMC4903018 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Tai Derek J C DJ Ragavendran Ashok A Manavalan Poornima P Stortchevoi Alexei A Seabra Catarina M CM Erdin Serkan S Collins Ryan L RL Blumenthal Ian I Chen Xiaoli X Shen Yiping Y Sahin Mustafa M Zhang Chengsheng C Lee Charles C Gusella James F JF Talkowski Michael E ME
Nature neuroscience 20160201 3
Recurrent, reciprocal genomic disorders resulting from non-allelic homologous recombination (NAHR) between near-identical segmental duplications (SDs) are a major cause of human disease, often producing phenotypically distinct syndromes. The genomic architecture of flanking SDs presents a challenge for modeling these syndromes; however, the capability to efficiently generate reciprocal copy number variants (CNVs) that mimic NAHR would represent a valuable modeling tool. We describe here a CRISPR ...[more]