Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis.
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ABSTRACT:
SUBMITTER: Ramke M
PROVIDER: S-EPMC4903898 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis.
Ramke Mirja M Zhou Xiaohong X Materne Emma Caroline EC Rajaiya Jaya J Chodosh James J
Experimental eye research 20160513
The cornea contains a heterogeneous population of antigen-presenting cells with the capacity to contribute to immune responses. Adenovirus keratitis is a severe corneal infection with acute and chronic phases. The role of resident corneal antigen-presenting cells in adenovirus keratitis has not been studied. We utilized transgenic MaFIA mice in which c-fms expressing macrophages and dendritic cells can be induced to undergo apoptosis, in a mouse model of adenovirus keratitis. Clinical keratitis ...[more]
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2016-07-28 | GSE64843 | GEO