The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions.

ABSTRACT: Renal dysfunction (RD) is a potent risk factor for death in patients with cardiovascular disease. This relationship may be causal; experimentally induced RD produces findings such as myocardial necrosis and apoptosis in animals. Cardiac transplantation provides an opportunity to investigate this hypothesis in humans.Cardiac transplantations from the United Network for Organ Sharing registry were studied (n?=?23,056). RD was defined as an estimated glomerular filtration rate?<60?mL/min/1.73?m(2). RD was present in 17.9% of donors and 39.4% of recipients. Unlike multiple donor characteristics, such as older age, hypertension, or diabetes, donor RD was not associated with recipient death or retransplantation (age-adjusted hazard ratio [HR]?=?1.00, 95% confidence interval [CI] 0.94-1.07, P?=?.92). Moreover, in recipients with RD the highest risk for death or retransplantation occurred immediately posttransplant (0-30 day HR?=?1.8, 95% CI 1.54-2.02, P?

SUBMITTER: Laur O 

PROVIDER: S-EPMC4904299 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature