Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Z
PROVIDER: S-EPMC5568853 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zheng Zhikun Z Chiu Stephen S Akbarpour Mahzad M Sun Haiying H Reyfman Paul A PA Anekalla Kishore R KR Abdala-Valencia Hiam H Edgren Daphne D Li Wenjun W Kreisel Daniel D Korobova Farida V FV Fernandez Ramiro R McQuattie-Pimentel Alexandra A Zhang Zheng J ZJ Perlman Harris H Misharin Alexander V AV Scott Budinger G R GR Bharat Ankit A
Science translational medicine 20170601 394
Primary graft dysfunction is the predominant driver of mortality and graft loss after lung transplantation. Recruitment of neutrophils as a result of ischemia-reperfusion injury is thought to cause primary graft dysfunction; however, the mechanisms that regulate neutrophil influx into the injured lung are incompletely understood. We found that donor-derived intravascular nonclassical monocytes (NCMs) are retained in human and murine donor lungs used in transplantation and can be visualized at si ...[more]