Ontology highlight
ABSTRACT:
SUBMITTER: Garg AD
PROVIDER: S-EPMC4905250 | biostudies-literature | 2015 Jan-Mar
REPOSITORIES: biostudies-literature
Garg Abhishek D AD Maes Hannelore H van Vliet Alexander R AR Agostinis Patrizia P
Molecular & cellular oncology 20141201 1
The endoplasmic reticulum (ER) is at the center of a number of vital cellular processes such as cell growth, death, and differentiation, crosstalk with immune or stromal cells, and maintenance of proteostasis or homeostasis, and ER functions have implications for various pathologies including cancer. Recently, a number of major hallmarks of cancer have been delineated that are expected to facilitate the development of anticancer therapies. However, therapeutic induction of ER stress as a strateg ...[more]