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Retinoblastoma family proteins: New players in DNA repair by non-homologous end-joining.

ABSTRACT: Loss of retinoblastoma protein (RB1) function is a major driver in cancer development. We have recently reported that, in addition to its well-documented functions in cell cycle and fate control, RB1 and its paralogs have a novel role in regulating DNA repair by non-homologous end joining (NHEJ). Here we summarize our findings and present mechanistic hypotheses on how RB1 may support the DNA repair process and the therapeutic implications for patients who harbor RB1-negative cancers.

SUBMITTER: Huang PH

PROVIDER: S-EPMC4905371 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Retinoblastoma family proteins: New players in DNA repair by non-homologous end-joining.

Huang Paul H PH Cook Rebecca R Zoumpoulidou Georgia G Luczynski Maciej T MT Mittnacht Sibylle S

Molecular & cellular oncology 20150610 2

Loss of retinoblastoma protein (RB1) function is a major driver in cancer development. We have recently reported that, in addition to its well-documented functions in cell cycle and fate control, RB1 and its paralogs have a novel role in regulating DNA repair by non-homologous end joining (NHEJ). Here we summarize our findings and present mechanistic hypotheses on how RB1 may support the DNA repair process and the therapeutic implications for patients who harbor RB1-negative cancers. ...[more]

PMID: 27308588

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Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.

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